Lab Rocker Bioreactors

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Lab Rocker Bioreactors

Single-use rocking bioreactor systems for process development and biomanufacuring.

BRS rocking bioreactor systems with single-use bags are designed for process development and seed train application.

BRS rocking bioreactor system is a reliable and intuitive cell culture system for working volumes up to 25 L. The system is based on a wellknown rocking technology that provides mixing and aeration to the culture, which is maintained in an inflated, disposable bioreactor cultivation chamber. Also it can control the rocker speed, tilt angle, gas flow, temperature, pH, DO, concentration of CO2, O2 and weight.

BRS lab rocker bioreactors support the replacement of trays of different sizes. 10L trays (2L, 5L, 10L culture bags), 20L trays (20L culture bags) and 50L trays (50L culture bags) optional.

Features

Tray replaced rapidly. 10L trays, 20L trays, 60L trays replaced easily. The trays are easily attached to the rocker when in the tilt position.

Suspension culture and adherent culture. Suitable for different cell culture bags, e.g, suspension cell culture and adherent cell culture. Continuous perfusion culture for adherent cell is achieved easily with our patented fabric carrier bag

Batch culture and perfusion culture of suspension cells. Perfusion membrane cell culture bag is used for the perfusion culture and high-density culture of suspension cells and the N-1 scale up.

Adherent cell trypsinization, transfer and scale up.

Application

Mammalian cells, insect cells, viruses, gene therapy, and cell therapy

Cell inoculums preparation (for suspended and adherent cells)

Manufacturing of antiviral vaccines for humans, as well as veterinary vaccines

Cell cultures for gene and cell therapy

Viral inoculum and viral vectors manufacturing

Specification

Tray size

10L

20L

50L

Total volume

2L / 5L / 10L

20L

50L

Max. working volume

1L / 2.5L / 5L

10L

25L

Control system

Siemens PLC, 15-inch color touch screen, Enthernet interface, USB interface

Temperature control

Heating plate, PID automatic control, accuracy: ±0.2˚C; Temperature control range: 5-40˚C above

Rocker speed

1-40 rpm

Tilt angle

1-12˚

Gas

3 Thermal mass flow controllers (Air/O2/CO2), a thermal mass flow controller with 3 gas mexer optional

Exhaust

Exhaust condenser, exhaust filter heater optional

Exhaust analysis

O2 (0-50%), CO2 (0-15%)

Pressure detection

Range: -100 mbar — 100 mbar; Stop air intake when it is exceeded

Single-use pH probe, control range: 6-8, accuracy: ±0.05 pH; PID control; cascaded by gas flow, peristaltic pump, etc.

Single-use DO probe, control range: 0-100%, accuracy: ±3%; PID control; cascaded by rocker speed, MFC, etc.

Pumps

4 fixed-speed peristaltic pumps, customized feeding / acid feeding / alkali feeding / discharging etc. 25 RPM or 100RPM variable speed optional

Load cell

Load: 0-50 kg, accuracy: ± (0.050 + 1% loading sampling) kg; cascaded by pumps

Utilities

Air / O2 / CO2, pressure 15-20 PSIG

Signal interface

Optional

Power supply

AC220V, 50/60 Hz, 10A